What do you like best?
Crossover is an alternative approach to run Windows applications in another environment (OSX, Linux). Not by running Windows, but by fooling Windows applications that they are running inside Windows.
It uses Wine (an Open Source system - Wine Is Not an Emulator - typical Linux recursive acronym) but packages it in a more user-oriented and friendly application. You don't really need it, but it makes it more convenient.
While initially focused on gaming, it has fair support for many business applications too.
Each application is (or can be) installed in a separate "Bottle", isolating it from others.
Performance was adequate.
What do you dislike?
It did not run the main applications I was hoping to run: Autodesk Revit and McNeel Rhinoceros with the Grasshopper plug-in.
The amount of out-of-the-box supported applications is still limited and they are often outdated versions of the applications (e.g. Office 2007, 2010).
The separation of applications into separate Bottles makes they more independent, but they take more space on your hard disk. This can become fairly big on smaller SSD drives.
Recommendations to others considering the product
Use the trial version and look out for promotional offers to get the license at 50%. It does solve some use cases, but not all. If you really rely on many Windows applications, it might be more convenient to use Bootcamp, Parallels or VMWare Fusion.
What business problems are you solving with the product? What benefits have you realized?
While it did help me to run a few Windows games directly inside my Mac, other applications had limited success. More specifically, I was aiming to get Rhinoceros + Grasshopper running. While I have been able to run Rhinoceros (even using our Network License at the University), other aspects of the software did not work (e.g. dragging the Grasshopper installer).
In practice, I have more success with Parallels and a full Windows 10 installation in the Bootcamp partition.