Endnote is a powerful reference manager for academics in general. It helps to keep all your sources organized and up to date. Among its many features, it has access to databases, allows the creation of groups of references for specific subjects/projects and has a tag and comment system that makes easier to find specific works.
Perhaps one of its most used features is a Word plugin that allows the inclusion of a citation with the corresponding reference in just a few clicks. Once such citation is in place, Endnote recreates the paper's bibliography to include the new source. Moreover, if you remove or change the citation, the reference changes accordingly, freeing the writer of worrying with orphan citations, a problem which was very common before reference managers.
Endnote also comes with dozens of reference styles and has a style manager that makes really easy to edit a style for a specific event like a conference or even to create a style from scratch.
One problem that I experienced was a program crash that damaged my reference database (called "Library" in Endnote). Since this kind of issue tend to happen more frequently in long texts with many references, it is recommended to make frequent backup of the library using the option "File > Compressed Library". Other recommendation for long and reference-heavy works is to divide the main text so that each chapter resides in one file.
It is one the best reference managers of the market and it will contribute greatly to writing academic papers.
I work both with research (writing papers for conferences and journals) and development (writing reports and technical projects). In both fields I find Endnote indispensable. Thanks to it, I saved many hours of tedious bookkeeping and improved the quality of my works.